• 
  Union de Santa Fe – Defensa

  10 October

• 
  Instituto – Boca Juniors

  9 October

• 
  Gimnasia y Esgrima LP – Atletico

  9 October

• 
  Aldosivi – Sarmiento

  9 October

• 
  Fluminense – Coritiba

  9 October

• 
  Palmeiras – Bahia

  9 October

• 
  Manchester – Tottenham

  10 October

• 
  Ipswich Town – Fulham

  10 October

• 
  Sunderland – Brighton

  10 October

• 
  Chelsea – Bournemouth

  10 October

• 
  Aston Villa – Brentford

  10 October

• 
  Arsenal – Leeds Utd

  10 October

• 
  AS Monaco – Toulouse

  10 October

• 
  PSG – Le Mans

  10 October

• 
  Lorient – Paris

  10 October

• 
  Brest – Angers

  10 October

• 
  Lille – Le Havre

  10 October

• 
  Lens – Lyon

  9 October

• 
  RB Leipzig – Eintracht

  10 October

• 
  Augsburg – Bayern Munich

  10 October

• 
  Dortmund – Werder Bremen

  9 October

• 
  Napoli – Frosinone

  10 October

• 
  Inter – Parma

  10 October

• 
  Genoa – Fiorentina

  10 October

• 
  Kashima Antlers – Gamba

  9 October

• 
  Ak Bars – Severstal

  10 October

• 
  Lokomotiv – Dinamo Mn

  10 October

• 
  Barys – Avangard

  10 October

• 
  Traktor – Sibir

  10 October

• 
  Admiral – Lada Tl

  10 October

• 
  Dynamo Msk – CSKA

  9 October

• 
  Sochi – Spartak M

  9 October

• 
  Metallurg Mg – Salavat

  9 October

• 
  UANL – Toluca

  10 October

• 
  Puebla – Leon

  10 October

• 
  Viseu – Estoril Praia

  10 October

• 
  Casa Pia – Santa Clara

  10 October

• 
  Maritimo – Porto

  10 October

• 
  Braga – Sporting

  9 October

• 
  FCSB – Otelul Galati

  10 October

• 
  Botosani – UTA Arad

  10 October

• 
  Sepsi OSK – Dinamo

  9 October

• 
  Corvinul – Voluntari

  9 October

• 
  Krasnodar – Zenit

  10 October

• 
  Krylia Sovetov – Spartak

  10 October

• 
  Fakel – Lokomotiv M

  10 October

• 
  Orenburg – Dynamo

  10 October

• 
  Rostov – Akron

  9 October

• 
  Real – Villarreal

  10 October

• 
  Barcelona – Getafe

  10 October