• 
  Instituto – Rio Cuarto

  15 September

• 
  Banfield – Barracas

  14 September

• 
  Deportivo – Lanus

  14 September

• 
  Union La Calera – Deportes

  15 September

• 
  America de Cali – Deportivo

  15 September

• 
  Leeds Utd – Newcastle

  14 September

• 
  Inter – Udinese

  14 September

• 
  Torino – Roma

  14 September

• 
  Como – Parma

  14 September

• 
  SKA – Kunlun RS

  15 September

• 
  Traktor – Lokomotiv

  15 September

• 
  Avangard – Avtomobilist

  15 September

• 
  Torpedo NN – Ak Bars

  14 September

• 
  Severstal – Dynamo Msk

  14 September

• 
  Lada Tl – Dinamo Mn

  14 September

• 
  Leon – Atletico

  15 September

• 
  Braga – Estoril Praia

  14 September

• 
  Rio Ave – Estrela

  14 September

• 
  FCSB – Petrolul

  14 September

• 
  U Cluj – Otelul Galati

  14 September

• 
  Elche – Real Madrid RM

  15 September

• 
  Alaves – Valencia

  15 September

• 
  Rayo – Espanyol

  15 September

• 
  Villarreal – Real Betis

  14 September

• 
  Gaziantep – Fenerbahce

  14 September

• 
  Shakhtar – Chornomorets

  14 September

• 
  Dynamo Kyiv – Epitsentr

  14 September

• 
  Arkadag – Al-Muharraq

  15 September

• 
  Gol Gohar – Al-Jazeera

  15 September

• 
  Al-Hilal – Al-Gharafa

  15 September

• 
  Al Ain – Al Nassr

  15 September

• 
  Johor DT – Buriram Utd

  15 September

• 
  Beijing Guoan – Pohang

  15 September

• 
  Ratchaburi – Shanghai

  15 September

• 
  Kashima Antlers – Newcastle

  15 September

• 
  Gamba Osaka – Cong An

  15 September

• 
  Daejeon Citizen – Kyoto

  15 September

• 
  Al – Pakhtakor

  14 September

• 
  Al Quadisiya – Al Wasl

  14 September

• 
  Esteghlal – Al-Sadd

  14 September

• 
  Shabab Al Ahli – Tractor

  14 September

• 
  Al-Shamal – Al-Ittihad

  14 September

• 
  Shafa – Sabah

  14 September

• 
  Ludogorets – Septemvri

  14 September

• 
  Lokomotiv GO – Nesebar

  15 September

• 
  Hebar – Etar

  14 September

• 
  Orsomarso – Atletico

  14 September

• 
  Tigres Bogota – Bogota

  14 September

• 
  Gorica – Varazdin

  14 September

• 
  Bristol City – Lincoln

  15 September