• 
  Huracan – Racing

  14 September

• 
  Independiente – San

  13 September

• 
  Argentinos Juniors – Gimnasia

  13 September

• 
  Sarmiento – Belgrano

  13 September

• 
  Tigre – Rosario Central

  13 September

• 
  Flamengo-RJ – Corinthians

  13 September

• 
  Mirassol – Vitoria-BA

  13 September

• 
  Santos-SP – Cruzeiro-MG

  13 September

• 
  Botafogo-RJ – RB

  13 September

• 
  Audax – O`Higgins

  14 September

• 
  Colo Colo – Deportes

  13 September

• 
  La Serena – Universidad

  13 September

• 
  Cucuta – Millonarios

  14 September

• 
  Once Caldas – Deportivo

  14 September

• 
  Atletico Nacional – Aguilas

  13 September

• 
  Deportivo Pereira – Atl

  13 September

• 
  Alianza Valledupar – Atletico

  13 September

• 
  Leeds Utd – Newcastle

  14 September

• 
  Manchester Utd – Manchester

  13 September

• 
  Coventry City – Brighton

  13 September

• 
  Brest – PSG

  13 September

• 
  Le Mans – Lens

  13 September

• 
  Lille – Troyes

  13 September

• 
  Elversberg – Bayern

  13 September

• 
  RB Leipzig – Hamburg

  13 September

• 
  Inter – Udinese

  14 September

• 
  Torino – Roma

  14 September

• 
  Como – Parma

  14 September

• 
  Sassuolo – Juventus

  13 September

• 
  Napoli – Bologna

  13 September

• 
  Lecce – Monza

  13 September

• 
  Urawa Reds – Fagiano

  13 September

• 
  Tokyo Verdy – JEF

  13 September

• 
  Torpedo NN – Ak Bars

  14 September

• 
  Severstal – Dynamo Msk

  14 September

• 
  Lada Tl – Dinamo Mn

  14 September

• 
  Neftekhimik – Admiral

  13 September

• 
  CSKA – Lokomotiv

  13 September

• 
  Avangard – Metallurg Mg

  13 September

• 
  Sibir – Avtomobilist

  13 September

• 
  Guadalajara – Pumas

  14 September

• 
  Santos Laguna – Juarez

  14 September

• 
  Cruz Azul – America

  13 September

• 
  Monterrey – UANL

  13 September

• 
  PSV – Sparta Rotterdam

  13 September

• 
  PEC Zwolle – Feyenoord

  13 September

• 
  Heerenveen – Telstar

  13 September

• 
  Excelsior – Utrecht

  13 September

• 
  Rio Ave – Estrela

  14 September

• 
  Famalicao – Sporting

  13 September